PANK2 polyclonal antibody

CAT: 0384-BS60437-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS60437-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
PANK2 (pantothenate kinase 2), also known as HSS, HARP, PKAN or NBIA1, is a ubiquitously expressed 570 amino acid member of the pantothenate kinase family of enzymes that are involved in the synthesis of coenzyme A (CoA) . Localized to the cytoplasm and mitochondria, PANK2 is thought to be the chief regulator of CoA biosynthesis, catalyzing the first of five steps in the biosynthetic pathway. Regulated by feedback inhibition from synthesized CoA, PANK2 catalyzes the ATP-dependent conversion of pantothenate to 4’-phosphopantothenate, thus initiating the first committed step in CoA biosynthesis. Defects in the gene encoding PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN) and hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa and pallidal degeneration (HARP) . PKAN and HARP are rare disorders characterized by extrapyramidal dysfunction and progressive dementia, both of which are caused by an accumulation of iron in the brain. PANK2 is expressed as three isoforms due to alternative splicing events.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Pantothenate kinase 2, mitochondrial; hPanK2; Pantothenic acid kinase 2; PANK2; C20orf48
Swiss Prot
Q9BZ23
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human PANK2.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 50 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PANK2 polyclonal antibody detects endogenous levels of PANK2 protein.
Applications Notes
Western blot (WB) analysis of PANK2 polyclonal antibody at 1:500 dilution Lane1:MCF-7 cell lysate Lane2:sp2/0 cell lysate Lane3:PC12 cell lysate
Host or Source
Rabbit

Related Products

CatalogName
BS76274-01PAN2 polyclonal antibody
BZ16794-01Polyclonal antibodyPN1 polyclonal antibody
BS90974Nudel polyclonal antibody
BS65808-01LCLAT1 Polyclonal Antibody
BS75650-01UBIAD1 polyclonal antibody
BS60338ADAM10 polyclonal antibody
BS77904-01NOP2 polyclonal antibody
BS79823-01ATF3 polyclonal antibody
BS74745-01MKLN1 polyclonal antibody
BS77708-01SMC3 polyclonal antibody

Alternative Products

CatalogName
MBS8532187-01PANK2 Polyclonal Antibody
MBS9516135-01PANK2 Rabbit Polyclonal Antibody
MF-0082368-01Anti-PANK2 Polyclonal Antibody
NBP2-88007Rabbit Polyclonal PANK2 Antibody
bs-8338R-RBITCPANK2 Polyclonal Antibody, RBITC Conjugated
bs-8338R-Cy3PANK2 Polyclonal Antibody, Cy3 Conjugated
bs-8338R-Cy7PANK2 Polyclonal Antibody, Cy7 Conjugated
bs-8338R-FITCPANK2 Polyclonal Antibody, FITC Conjugated
bs-8338R-PerCPPANK2 Polyclonal Antibody, PerCP Conjugated
PAV2921Rabbit Anti-PANK2 Polyclonal Antibody

Popular Products