PAK6 polyclonal antibody

• Background :

  The p21 (CDKN1A) -activated kinases (PAKs) are serine/threonine protein kinases that bind to activated small GTPases, including Cdc42 and Rac, and influence transcription, cell morphology (cytoskeleton rearrangement), motility, and apoptosis. PAK family members contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK6 protein cotranslocates into the nucleus with androgen receptor, which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development, in response to androgen. PAK6 transcripts are present at high levels in brain and testis, with lower levels in multiple tissues including prostate and breast.

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative :

  Serine/threonine-protein kinase PAK 6; PAK-5; p21-activated kinase 6; PAK-6; PAK6; PAK5

• Swiss Prot :

  Q9NQU5

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  A synthetic peptide corresponding to residues in Human PAK6.

• Conjugation :

  Unconjugated

• Applications :

  WB

• Dilution :

  WB: 1:500~1:1000

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodification

• Molecular Weight :

  ~ 75 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  PAK6 polyclonal antibody detects endogenous levels of PAK6 protein.

• Applications Notes :

  Western blot (WB) analysis of PAK6 polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:Mouse brain tissue lysate Lane3:Rat brain tissue lysate

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4