Stat5b polyclonal antibody

• Background:

  Stat5a and Stat5b (signal transducer and activator of transcription 5a and 5b; 96% homology) undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus where they initiate transcription. Activation of Stat5b via IL-2, IL-4, CSF1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with retinoic acid receptor-α gene in acute promyelocytic leukemias (APLL) .

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  Signal transducer and activator of transcription 5B; STA5B; STAT5; Stat5b; Transcription factor STAT5B

• Swiss Prot:

  P51692

• Reactivity:

  Human, Rat

• Immunogen:

  Recombinant full length Human Stat5b.

• Conjugation:

  Unconjugated

• Related Pathways:

  Immune Cell Signaling, Jak Stat : IL-6 Receptor Signaling

• Applications:

  WB IF

• Dilution:

  WB: 1:500~1:2000 IF: 1:50~1:200

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 90 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  STAT5B polyclonal antibody detects endogenous levels of STAT5B protein.

• Applications Notes:

  WesternBlot (WB) analysis of STAT5B polyclonal antibody in extracts from K562, PC12, MCF7 and HepG2 cells.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4