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RGL1 polyclonal antibody

CAT: 0384-BS60212-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS60212-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ral GDS (Ral guanine nucleotide dissociation stimulator) is a guanine nucleotide exchange factor (GEF) that activates Ral and is implicated in oncogenic Ras-induced cell transformation. RGL1 (ral guanine nucleotide dissociation stimulator-like 1), also known as RGL or RalGDS-like 1, is a 768 amino acid protein that is a putative GEF. Strongly expressed in brain, heart, spleen, kidney and testis, RGL1 is a downstream effector protein that is involved in Ras and Ral signaling pathways. RGL1 contains an N-terminal Ras-GEF domain and a C-terminal Ras-interacting domain that interacts with the GTP-bound form of Ras through its effector loop. Due to its similarity to Ral GDS, RGL1 may be implicated in carcinogenesis. Two isoforms exist due to alternative splicing events.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Ral guanine nucleotide dissociation stimulator-like 1; RalGDS-like 1; KIAA0959; RGL
Swiss Prot
Q9NZL6
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human RGL1.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 87 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
RGL1 polyclonal antibody detects endogenous levels of RGL1 protein.
Applications Notes
Western blot (WB) analysis of RGL1 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:NIH-3T3 whole cell lysate Lane3:PC12 whole cell lysate
Host or Source
Rabbit

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