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XRCC4 polyclonal antibody

CAT: 0384-BS60079-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS60079-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V (D) J recombination. Any defect in one of the known components of the DNA repair/V (D) J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V (D) J rearrangement process and early block in both T and B cell maturation.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
DNA repair protein XRCC4; X-ray repair cross-complementing protein 4; XRCC4
Swiss Prot
Q13426
Reactivity
Human, Mouse
Immunogen
A synthetic peptide corresponding to residues in Human XRCC4.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 38 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
XRCC4 polyclonal antibody detects endogenous levels of XRCC4 protein.
Applications Notes
Western blot (WB) analysis of XRCC4 polyclonal antibody at 1:500 dilution Lane1:MCF-7 whole cell lysate Lane2:HEK293T whole cell lysate Lane3:NIH-3T3 whole cell lysate
Host or Source
Rabbit

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