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Septin 6 polyclonal antibody

CAT: 0384-BS5925-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS5925-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Septin 6, also known as SEPT6, is a 434 amino acid protein that belongs to the septin family. The highly conserved septin family of GTP-binding cytoskeletal proteins is implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis and other cellular functions. Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. Filaments are assembled from asymmetrical heterotrimers, composed of Septin 2, Septin 6 and Septin 7 that associate head-to-head to form a hexameric unit, however interaction with Septin 12 alters filament structure. Septin 6 shares 40% identity with CDC10 and contains an ATP/GTP-binding site motif. The Septin 6 protein demonstrates nearly ubiquitous expression, with highest level in thymus. The Septin 6 protein is phosphorylated upon DNA damage, probably by Atm or ATR.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Septin6; Septin-6; SEPT6; KIAA0128; SEP2
Swiss Prot
Q14141
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 267-312 of Human Septin 6.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 50 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Septin 6 polyclonal antibody detects endogenous levels of Septin 6 protein.
Applications Notes
Western blot (WB) analysis of Septin 6 polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:sp2/0 cell lysate Lane3:PC12 cell lysate
Host or Source
Rabbit

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