RPS19 polyclonal antibody

Ribosomal subunits are synthesized in the nucleus and mature 40S and 60S subunits are exported stoichiometrically into the cytoplasm. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. Ribosomal proteins have the ability to pass through the nu-clear envelope in the native state, making them the largest of the structures accommodated by the nuclear pore complexes. The nuclear export of ribosomal subunits is a unidirectional, saturable and energy-dependent process. Ribosomal Protein S19 (RPS19) is a 145 amino acids protein expressed in various human adult tissues, including bone marrow, peripheral blood, spleen, liver and nonhematopoietic tissues. RPS19 expression decreases during terminal erythroid differentiation; a deficiency of RPS19 blocks proliferation of immature erythroid progenitor cells altogether. Muta-tions in the RPS19 gene are linked with Diamond-Blackfan anemia (DBA), a congenital, hypo-plastic, red cell aplasia that occasionally presents with physical anomalies.

9007-83-4

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

40S ribosomal protein S19

P39019

Human, Mouse, Rat

Synthetic peptide, corresponding to amino acids 100-145 of Human RPS19.

Unconjugated

WB IHC

WB: 1:500~1:1000 IHC: 1:50~1:200

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Unmodification

~ 16 kDa

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.

RPS19 polyclonal antibody detects endogenous levels of RPS19 protein.

Western blot (WB) analysis of RPS19 polyclonal antibody at 1:500 dilution Lane1:HEK293T cell lysate Lane2:Raw264.7 cell lysate Lane3:PC12 cell lysate