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PRPF18 polyclonal antibody

CAT: 0384-BS5866-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS5866-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PRPF18 (pre-mRNA-splicing factor 18), also known as HPRP18, is a 342 amino acid protein that localizes to nuclear speckles and plays a role in the second step of pre-mRNA splicing. A member of the PRP18 family, PRPF18 contains seven WD repeats and exists as two alternatively spliced isoforms which are encoded by a gene located on human chromosome 10p13. Chromosome 10 contains over 800 genes and 135 million nucleotides. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. Other chromosome 10 associated disorders include Cockayne syndrome, tetrahydrobiopterin deficiency and trisomy 10.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Pre-mRNA-splicing factor 18; PRP18 homolog; hPRP18; PRP18; HPRP18
Swiss Prot
Q99633
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 223-268 of Human PRPF18.
Conjugation
Unconjugated
Applications
WB ICC
Dilution
WB: 1:500~1:1000 ICC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 40 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PRPF18 polyclonal antibody detects endogenous levels of PRPF18 protein.
Applications Notes
Western blot (WB) analysis of PRPF18 polyclonal antibody at 1:500 dilution Lane1:HEK29T cell lysate Lane2:sp2/0 cell lysate Lane3:H9C2 cell lysate
Host or Source
Rabbit

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