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CACNG1 polyclonal antibody

CAT: 0384-BS5785-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS5785-01Size:50 µL
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Background
Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an α1 subunit, a β subunit, a γ subunit and an α2δ subunit. The β subunit is encoded by four genes, designated β1-β4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the α1 subunit. L-type Ca ++ CP γ1, also known as CACNLG or CACNG1, is a 222 amino acid multi-pass membrane protein belonging to the PMP-22/EMP/MP20 family. Expressed in skeletal muscle, L-type Ca ++ CP γ1 is a subunit of the dihydropyridine (DHP) sensitive calcium channel and may play a role in excitation-contraction coupling. L-type Ca++ CP γ1 is considered a novel marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant disorder of skeletal muscle which manifests as a life-threatening hypermetabolic crisis triggered by commonly used inhalation anaesthetics and depolarizing muscle relaxants.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Voltage-dependent calcium channel gamma-1 subunit; Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma; CACNLG; L-type Ca++ CP γ1; L-type Ca++ CPγ1
Swiss Prot
Q06432
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to the 177-222 of Human CACNG1.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 25 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CACNG1 polyclonal antibody detects endogenous levels of CACNG1 protein.
Applications Notes
Western blot (WB) analysis of CACNG1 polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:sp2/0 cell lysate Lane3:H9C2 cell lysate
Host or Source
Rabbit

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