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IFITM3 polyclonal antibody

CAT: 0384-BS5762-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS5762-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IFITM3 (interferon induced transmembrane protein 3), also known as 1-8U or IP15, is a multi-pass membrane protein that belongs to the IFITM (interferon inducible transmembrane) family of proteins. IFITM proteins are induced by type I and type II interferons and contain multiple interferon (IFN) -stimulated response elements (ISREs) in their promoter regions. IFITM proteins play important roles in many cellular processes and their expression requires the presence of the chromatin remodeling SWI/SNF-like BAF complexes. Cellular processes involving IFITM proteins include cellular anti-proliferative activities and homotypic cell adhesion functions of interferons. In addition, IFITM genes are often upregulated in various cancer cells, suggesting a possible role in carcinogenesis. Localizing to the membrane, IFITM3 is a 133 amino acid protein that is induced by IFN-α and IFN-γ. IFITM3 expression can be regulated by TEF-1, Brg-1 and Sp1.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Interferon-induced transmembrane protein 3; Dispanin subfamily A member 2b; DSPA2b; Interferon-inducible protein 1-8U; Fragilis
Swiss Prot
Q01628
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 9-54 of Human IFITM3.
Conjugation
Unconjugated
Applications
WB ICC
Dilution
WB: 1:500~1:1000 ICC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 15 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IFITM3 polyclonal antibody detects endogenous levels of IFITM3 protein.
Applications Notes
Western blot (WB) analysis of IFITM3 polyclonal antibody at 1:500 dilution Lane1:HEK293T cell lysate Lane2:Raw264.7 cell lysate Lane3:H9C2 cell lysate
Host or Source
Rabbit

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