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SLC25A12 polyclonal antibody

CAT: 0384-BS5616-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS5616-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca (2+) entry in mitochondria via the Ca (2+) uniporter followed by Ca (2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca (2+) -binding mitochondrial aspartate-glutamate carrier, has Ca (2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS) . ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca (2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Calcium-binding mitochondrial carrier protein Aralar1; Mitochondrial aspartate glutamate carrier 1; Solute carrier family 25 member 12; ARALAR1
Swiss Prot
O75746
Reactivity
Human, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 435-480 of Human SLC25A12.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 74 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SLC25A12 polyclonal antibody detects endogenous levels of SLC25A12 protein.
Applications Notes
Western blot (WB) analysis of SLC25A12 polyclonal antibody at 1:500 dilution Lane1:Jurkat cell lysate Lane2:Rat liver tissue lysate
Host or Source
Rabbit

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