HDAC1 (E427) polyclonal antibody

CAT: 0384-BS5576-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS5576-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated mammalian RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Histone deacetylase 1; HD1; RPD3L1
Swiss Prot
Q13547
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 398-446 of Human HDAC1.
Conjugation
Unconjugated
Related Pathways
Notch Signaling, Nuclear Receptor Signaling, Cell Cycle Control G1 S Checkpoint, DNA Methylation, Epigenetic Writers and Erasers of Histone H3, Epigenetic Writers and Erasers of Histones H2A H2B and H4
Applications
IHC
Dilution
IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 55 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
HDAC1 (E427) polyclonal antibody detects endogenous levels of HDAC1 protein.
Host or Source
Rabbit

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