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PDK2 (R291) polyclonal antibody

CAT: 0384-BS3913-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS3913-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The core of PDC is composed of sixty dihydrolypoyl acetyltransferase (E2) subunits that bind directly to PDK2 and enhance PDK2 kinase activity. Upregulation of PDK isoenzymes occurs during starvation conditions, rerouting acetyl-CoA generation by facilitating fatty acid oxidation. PDKs contain five conserved regions and are mechanistically similar to bacterial His-kinases, in that both require histidine residues for activity. In mammals, transcripts for PDK2 are ubiquitously expressed with high levels in heart and skeletal muscle and decreased levels in spleen and lung.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2; mitochondrial; PDHK2; PDK2; PDK2; Pyruvate dehydrogenase kinase isoform 2; Pyruvate dehydrogenase kinase; isozyme 2; Pyruvate dehydrogenase lipoamide kinase isozyme 2; mitochondrial
Swiss Prot
Q15119
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 260-322 of Human PDK2.
Conjugation
Unconjugated
Applications
WB IHC IP
Dilution
WB 1:500 - 1:1000 IHC 1:50 - 1:100 IP 1:10 - 1:100
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 46 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PDK2 (R291) polyclonal antibody detects endogenous levels of PDK2 protein.
Applications Notes
Western blot (WB) analysis of PDK2 (R291) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate (40ug) Lane2:L02 whole cell lysate (40ug) Lane3:The brain tissue lysate of Mouse (40ug) Lane4:The brain tissue lysate of Rat (40ug) Lane5:The liver tissue lysate of Mouse (40ug) Lane6:The liver tissue lysate of Rat (40ug)
Host or Source
Rabbit

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