SEMA3C (E750) polyclonal antibody

CAT: 0384-BS3705-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS3705-01Size:50 µL
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Background
SEMA3C (also designated Semaphorin 3C, Semaphorin E, SEMAE, SemE, sema domain, immunoglobulin domain (Ig) and short basic domain, secreted) is an ubiquitous protein of approximately 70 kDa that mediates axonal guidance, repulsive gradients, induction of growth cone collapse and cell survival/death. Secreted SEMA3C favors survival and neuritogenesis of cultured cerebellar granule neurons (CGNs) . SEMA3C from macrophages and fibroblasts that selectively directs against sympathetic nerve fibers may be one element responsible for reduced sympathetic innervation in rheumatoid arthritis tissue.SEMA3C mutant mice die within hours after birth from congenital cardiovascular defects consisting of interruption of the aortic arch and improper septation of the cardiac outflow tract. SEMA3C is expressed in the cardiac outflow ract as neural crest cells and promotes crest cell migration into the proximal cardiac outflow tract.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Semaphorin-3C; Semaphorin-E; Sema E; SEMAE; SEMA3C
Swiss Prot
Q99985
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 713-768 of Human SEMA3C.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 85 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SEMA3C (E750) polyclonal antibody detects endogenous levels of SEMA3C protein.
Applications Notes
Western blot (WB) analysis of SEMA3C (E750) polyclonal antibody at 1:500 dilution Lane1:MCF-7 whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate
Host or Source
Rabbit

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