Integrin β3 (S778) polyclonal antibody

CAT: 0384-BS3660-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS3660-01Size:50 µL
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Background
Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16α and 8β subunits heterodimerize to produce more than 20 different receptors. Most Integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain Integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster Integrins by binding to adjacent Integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of Integrinmediated responses.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Integrin beta-3; Platelet membrane glycoprotein IIIa; Short name=GPIIIa; CD_antigen=CD61; ITGB3; GP3A; CD61; GPIIIa
Swiss Prot
P05106
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 751-800 of Human Integrin β3.
Conjugation
Unconjugated
Related Pathways
Tumor Angiogenesis, Contribution of ECM and Cytoskeletal Factors to EMT
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 87, 110 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Integrin β3 (S778) polyclonal antibody detects endogenous levels of Integrin β3 protein.
Applications Notes
Western blot (WB) analysis of Integrin β3 (S778) pAb at 1:500 dilution Lane1:BV2 whole cell lysate (40ug) Lane2:RAW264.7 whole cell lysate (40ug) Lane3:The Uterus tissue lysate of Rat (40ug) Lane4:THP-1 whole cell lysate (40ug) Lane5:A549 whole cell lysate (40ug) Lane6:PC3 whole cell lysate (40ug) Lane7:U-87MG whole cell lysate (40ug)
Host or Source
Rabbit

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