Products for Research Use Only
RegisterLogin

4E-BP1 (G39) polyclonal antibody

CAT: 0384-BS3613-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0384-BS3613-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The translation of proteins from eukaryotic mRNA is initiated by the multisubunit complex eIF-4F, which associates with the mRNA 5' cap structure. eIF-4E, a component of eIF-4F, is responsible for binding to the 5' cap structure and for the assembly of the eIF-4F complex. The regulatory protein 4E-BP1, also referred to as PHAS-I, inhibits eIF-4E function. Phosphorylation of 4E-BP1 by S6 kinase p70, MAP kinases or PKCs causes the disassociation of 4E-BP1 from eIF-4E, promoting translation. A protein that is functionally related to 4E-BP1, designated 4E-BP2, also associates with eIF-4E.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I; EIF4EBP1; 4EBP1; PHAS I; PHASI
Swiss Prot
Q13541
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 17-60 of Human 4E-BP1.
Conjugation
Unconjugated
Related Pathways
PI3K AKT signaling, Hypoxia Signaling, Insulin &Glucose Signaling, MTOR signaling
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 15 to 20 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
4E-BP1 (G39) polyclonal antibody detects endogenous levels of 4E-BP1 protein.
Applications Notes
Western blot (WB) analysis of 4E-BP1 (G39) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate (40ug) Lane2:PC3 whole cell lysate (40ug) Lane3:The Ovary tissue lysate of Rat (40ug) Lane4:The Embryo tissue lysate of Mouse (40ug)
Host or Source
Rabbit

Related Products

CatalogName
BZ162834E BP1 polyclonal antibody
BZ16996-014E BP1 polyclonal antibody
BS900074E-BP1 polyclonal antibody
BS13764E-BP1 (N63) polyclonal antibody
BS36124E-BP1 (P30) polyclonal antibody
BS13754E-BP1 (L58) polyclonal antibody
MB108714E BP1 monoclonal antibody
BS4747-014E-BP1 (phospho-T46) polyclonal antibody
BS5001-014E-BP1 (phospho-S65) polyclonal antibody
AP0525-014E-BP1 (Phospho-Ser64) polyclonal antibody

Alternative Products

CatalogName
E43S36134E-BP1 (G39) polyclonal antibody
JOT-AP00036-014E-BP1 Polyclonal Antibody
GTR18300803-014E BP1 polyclonal antibody

Popular Products