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ALK (W1503) polyclonal antibody

CAT: 0384-BS3243-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS3243-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
LTK, ALK and Ros have been identified as receptor tyrosine kinases having sequence similarity to the Insulin receptor subfamily of kinases. LTK, leukocyte tyrosine kinase, is expressed in murine B lymphocyte precursors and has also been found in forebrain neurons. ALK, anaplastic lymphoma kinase, is normally highly expressed specifically in the nervous system. A truncated form containing the catalytic domain of ALK is expressed as the result of a translocation occuring in many non-Hodgkin’s lymphomas. The c-Ros gene was originally identified in mutant form as an oncogene. Ros is normally expressed in a small number of epithelial cell types and may play a role in epithelial development.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246; ALK
Swiss Prot
Q9UM73
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 1470-1523 of Human ALK.
Conjugation
Unconjugated
Related Pathways
ErbB HER Signaling
Applications
IHC
Dilution
IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 170 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ALK (W1503) polyclonal antibody detects endogenous levels of ALK protein.
Host or Source
Rabbit

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