Products for Research Use Only
RegisterLogin

XRN2 polyclonal antibody

CAT: 0384-BS3015-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0384-BS3015-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Degradation of mRNA is a critical aspect of gene expression that occurs via the exoribonuclease. Exoribonuclease 2 (XRN2) is the human homolog of the Saccharomyces cerevisiae RAT1, which functions as a nuclear 5' to 3' exoribonuclease and is essential for mRNA turnover and cell viability. XRN2 also processes rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus. XRN2 moves along with RNA polymerase II and gains access to the nascent RNA transcript after the endonucleolytic cleavage at the poly (A) site or at a second cotranscriptional cleavage site (CoTC) . CoTC is an autocatalytic RNA structure that undergoes rapid self-cleavage and acts as a precursor to termination by presenting a free RNA 5' end to be recognized by XRN2. XRN2 then travels in a 5'-3' direction like a guided torpedo and facilitates the dissociation of the RNA polymerase elongation complex.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
5'-3' exoribonuclease 2 ; DHM1-like protein; DHP protein; XRN2
Swiss Prot
Q9H0D6
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding Human XRN2.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 110 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
XRN2 polyclonal antibody detects endogenous levels of XRN2 protein.
Applications Notes
Western blot (WB) analysis of XRN2 polyclonal antibody at 1:500 dilution Lane1:PC3 whole cell lysate (20ug) Lane2:A2780 whole cell lysate (20ug) Lane3:SK-OVCAR3 whole cell lysate (40ug) Lane4:CT26 whole cell lysate (40ug)
Host or Source
Rabbit

Related Products

CatalogName
PPL02162-4aPLenti-CMV-Flag-XRN2-GFP-Puro
MB67147-01XRN1 monoclonal antibody
BZ16794-01Polyclonal antibodyPN1 polyclonal antibody
BS75206-01AaaaaASPH polyclonal antibody
BS5662-01CHST1 polyclonal antibody
BS71123-01COPS7A polyclonal antibody
BS65479-01GDN Polyclonal Antibody
BS8691-01TUSC2 polyclonal antibody
BS72779-01FBLIM1 polyclonal antibody
BZ16836APE1 polyclonal antibody

Alternative Products

CatalogName
MBS9245585-01XRN2 Polyclonal Antibody
MBS9450160-01XRN2 Polyclonal Conjugated Antibody
NBP2-13529Rabbit Polyclonal XRN2 Antibody
APRab19977-01XRN2 Rabbit Polyclonal Antibody

Popular Products