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TWEAK (P73) polyclonal antibody

CAT: 0384-BS2454-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS2454-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TWEAK is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. It is widely expressed, has high constitutive expression in heart placenta, lung, muscle, kidney, pancreas, and HUVEC. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. TWEAK can induce apoptosis via multiple pathways of cell death in a cell type specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Tumor necrosis factor ligand superfamily member 12; APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK; TNFSF12; APO3L; DR3LG; UNQ181/PRO207
Swiss Prot
O43508
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to amino acids 51-100 of Human TWEAK.
Conjugation
Unconjugated
Applications
WB IHC IF
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 27 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
TWEAK (P73) polyclonal antibody detects endogenous levels of TWEAK protein.
Applications Notes
Western blot (WB) analysis of TWEAK (P73) polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate (40ug) Lane2:U-87MG whole cell lysate (40ug) Lane3:HEK293T whole cell lysate (40ug) Lane4:A2780 whole cell lysate (40ug) Lane5:SP2/0 whole cell lysate (40ug) Lane6:C6 whole cell lysate (40ug) Lane7:PC12 whole cell lysate (40ug)
Host or Source
Rabbit

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