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PBF (R151) polyclonal antibody

CAT: 0384-BS2285-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS2285-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PBF, also known as PTTG1IP (pituitary tumor-transforming 1 interacting protein), is a 180 amino acid single-pass type I membrane protein that localizes both the cytoplasm and the nucleus and contains a coiled-coil domain. Expressed ubiquitously, PBF interacts with PTTG and is thought to facilitate the nuclear translocation of PTTG, thereby allowing the PTTG-dependent transcriptional activation of fibroblast growth factor (FGF) . The gene encoding PBF maps to human chromosome 21, which houses approximately 300 genes and comprises nearly 1.5% of the human genome. Chromosome 21-associated disorders include Alzheimer’s disease, amyotrophic lateral sclerosis and, most notably, Down syndrome (also known as trisomy 21) .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
PTTG binding factor; PTTG-binding factor; PTTG; Pttg1ip; PBF; PTTG1IP
Swiss Prot
P53801
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to amino acids 130-180 of Human PBF.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 22 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PBF (R151) polyclonal antibody detects endogenous levels of PBF protein.
Applications Notes
Western blot (WB) analysis of PBF (R151) pAb at 1:500 dilution Lane1:Panc1 whole cell lysate (40ug) Lane2:SGC7901 whole cell lysate (40ug) Lane3:A375 whole cell lysate (40ug)
Host or Source
Rabbit

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