ATP6 polyclonal antibody

• Background:

  ATP6, also known as MT-ATP6, ATPASE6 or MTATP6, is a 226 amino acidmulti-passmembrane protein that localizestomitochondria and functions as a component of the F0 proton channel, playing a direct role in the transport of protons acrossthe mitochondrial membrane. Defectsin the gene encoding ATP6 are the cause of infantile bilateralstriatal necrosis, Leigh syndrome (LS), Leber hereditary optic neuropathy (LHON) and neurogenic muscle weakness, ataxia, and retinitis pigmentosa (NARP), all of which are neurological or retinal disorders. The gene encoding ATP6 exists as part of themitochondrial genome.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  ATP synthase subunit a; F-ATPase protein 6; Mtatp6; Atp6; Atpase6; mt-Atp6

• Swiss Prot:

  P00848

• Reactivity:

  Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to amino acids 55-70 of Mouse ATP6.

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB: 1:500~1:1000 IHC: 1:50~1:200

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 25 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  ATP6 polyclonal antibody detects endogenous levels of ATP6 protein.

• Applications Notes:

  Western blot (WB) analysis of ATP6 polyclonal antibody at 1:1000 dilution Lane1:The muscle tissue lysate of Rat (47μg) Lane2:The muscle tissue lysate of Mouse (37μg)

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4