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ND4L polyclonal antibody

CAT: 0384-BS1633-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS1633-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NADH:ubiquinone oxidoreductase (complex I) is an extremely complicated multiprotein complex located in the inner mitochondrial membrane. Human complex I is important for energy metabolism because its main function is to transport electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. Human complex I appears to consist of 41 subunits. A small number of complex I subunits are the products of mitochondrial genes (subunits 1-7), while the remainder are nuclear encoded and imported from the cytoplasm. NADH dehydrogenase subunit 4L (ND4L) is most likely a component of the hydrophobic protein fragment of Complex I. Mutations in the gene encodiing for ND4 are implicated in Leber hereditary optic neuropathy, a rare condition that can cause loss of central vision.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
NADH-ubiquinone oxidoreductase chain 4L (EC:1.6.5.3) ; NADH dehydrogenase subunit 4L; Mtnd4l; mt-Nd4l; Nd4l
Swiss Prot
P03903
Reactivity
Mouse
Immunogen
A synthetic peptide corresponding to amino acids 80-97 of Mouse ND4L.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 10 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ND4L polyclonal antibody detects endogenous levels of ND4L protein.
Applications Notes
Western blot (WB) analysis of ND4L polyclonal antibody at 1:1000 dilution Lane1:NIH/3T3 whole cell lysate (48μg)
Host or Source
Rabbit

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