Stat4 (E687) polyclonal antibody

CAT: 0384-BS1337-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS1337-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expresion of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Signal transducer and activator of transcription 4; Stat-4; Stat 4
Swiss Prot
Q14765
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 658-705 of Human Stat4.
Conjugation
Unconjugated
Related Pathways
Jak Stat : IL-6 Receptor Signaling
Applications
IHC IP
Dilution
IHC: 1:50~1:200 IP: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 88 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
STAT4 (E687) polyclonal antibody detects endogenous levels of STAT4 protein.
Host or Source
Rabbit

Related Products

CatalogName
BS1104EGFR (E687) polyclonal antibody
BS91287STAT4 polyclonal antibody
BS78368STAT4 polyclonal antibody
BS71900-01STAT4 polyclonal antibody
BS4183-01Stat4 (phospho-Y693) polyclonal antibody
BS74129-01Phospho-STAT4-Y693 polyclonal antibody
MB12259-01STAT4 monoclonal antibody
PPL00564-2aPCMV-Flag-STAT4
BS2341-01PHKB (E689) polyclonal antibody
PPL00564-2bPGL4.19-STAT4 response element

Alternative Products

CatalogName
A00734Anti-Stat4 (E687) Antibody
MBS8525428-01Stat4 Polyclonal Antibody

Popular Products