Products for Research Use Only

JunB (D253) polyclonal antibody

CAT: 0384-BS1196-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS1196-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein along with c-Fos is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Homo- and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE) . Two additional genes, Jun B and Jun D have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in ranscriptional activation, diverge. All three form heterodimers among themselves and with c-Fos and other members of the Fos gene family.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
JunB; Jun B; Jun B proto oncogene; Transcription factor jun-B
Swiss Prot
P17275
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 220-270 of Human JunB.
Conjugation
Unconjugated
Related Pathways
ESC Pluripotency and Differentiation Signaling Pathway
Applications
IHC IP
Dilution
IHC: 1:50~1:200 IP: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 43 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
JunB (D253) polyclonal antibody detects endogenous levels of JunB protein.
Host or Source
Rabbit