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ERα (L100) polyclonal antibody

CAT: 0384-BS1114-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS1114-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ERα and ERβ, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. ERα and ERβ have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ERα and ERβ may be regulated by distinct mechanisms even though they share many functional characteristics.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Estrogen receptor; ER-alpha; ER; ESR1; ESR; NR3A1
Swiss Prot
P03372
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 61-110 of Human ERα.
Conjugation
Unconjugated
Related Pathways
Nuclear Receptor Signaling
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 66 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Estrogen Receptor-α (L100) polyclonal antibody detects endogenous levels of Estrogen Receptor-α protein.
Applications Notes
Western blot (WB) analysis of ERα (L100) polyclonal antibody at 1:500 dillution Lane1:MCF-7 whole cell lysate (40μg) Lane2:NIH-3T3 whole cell lysate (40μg) Lane3:H9C2 whole cell lysate (40μg)
Host or Source
Rabbit

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