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Bax (S4) polyclonal antibody

CAT: 0384-BS1030-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS1030-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The Bcl-2 gene was isolated at the chromosomal breakpoint of t-bearing follicular B cell lymphomas. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Bcl-2 is localized to outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes. A related protein, designated Bax p21 (for Bcl-associated X protein), has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Apoptosis regulator BAX; Bcl-2-like protein 4; Bcl2-L-4; BAX; BCL2L4
Swiss Prot
Q07812
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to the N-terminus of Human Bax.
Conjugation
Unconjugated
Related Pathways
Regulation of Apoptosis, SAPK JNK Signaling Cascades, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis
Applications
WB IHC IP
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200 IP: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 21 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Bax (S4) polyclonal antibody detects endogenous levels of Bax protein.
Applications Notes
Western blot (WB) analysis of Bax (S4) polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate (40ug) Lane2:K562 whole cell lysate (40ug) Lane3:MCF-7 whole cell lysate (40ug)
Host or Source
Rabbit

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