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SLC16A5 (A193) polyclonal antibody

CAT: 0384-AP0702-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-AP0702-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. MCT6 is highly expressed in the kidneys and is thought to have a specificity for bumetanide, a loop diuretic involved in the treatment of edema. The high substrate specificity of MCT6 suggests a possible role in therapeutic drug transport and trafficking across the plasma membrane.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Monocarboxylate transporter 6; MCT 6; Monocarboxylate transporter 5; MCT 5; Solute carrier family 16 member 5; SLC16A5; MCT5; MCT6
Swiss Prot
O15375
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 161-210 of Human SLC16A5.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 55 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SLC16A5 (A193) polyclonal antibody detects endogenous levels of SLC16A5 protein.
Applications Notes
Western blot (WB) analysis of SLC16A5 (A193) polyclonal antibody at 1:500 dillution Lane1:HEK293T whole cell lysate (40μg) Lane2:NIH-3T3 whole cell lysate (40μg) Lane3:PC12 whole cell lysate (40μg)
Host or Source
Rabbit

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