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POLI polyclonal antibody

CAT: 0384-BS61707-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS61707-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA pol ι (pol iota), which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol ι is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol ι also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol ι acts sequentially with DNA Pol ζ, which is essential for damageinduced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol ι is likely to be highly mutagenic.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
DNA polymerase iota; Eta2; RAD30 homolog B; POLI; RAD30B
Swiss Prot
Q9UNA4
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to amino acids 630-680 of Human POLI.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 83 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
POLI polyclonal antibody detects endogenous levels of POLI protein.
Applications Notes
Western blot (WB) analysis of POLI polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate (40ug) Lane2:A375 whole cell lysate (40ug) Lane3:HCT116 whole cell lysate (40ug) Lane4:SGC7901 whole cell lysate (40ug)
Host or Source
Rabbit

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