DSC2 polyclonal antibody

• Background :

  This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative :

  DG2; DSC3; CDHF2; ARVD11; DGII/III

• Swiss Prot :

  Q02487

• Reactivity :

  Human

• Immunogen :

  Recombinant protein of human DSC2

• Conjugation :

  Unconjugated

• Applications :

  WB

• Dilution :

  WB 1:1000 - 1:2000

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodification

• Molecular Weight :

  ~ 100 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  DSC2 polyclonal antibody detects endogenous levels of DSC2 protein.

• Applications Notes :

  Western blot analysis of extract of various cells, using DSC2 antibody.

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4