DSC2 polyclonal antibody

CAT: 0384-BS71520-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS71520-01Size:50 µL
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Background
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
DG2; DSC3; CDHF2; ARVD11; DGII/III
Swiss Prot
Q02487
Reactivity
Human
Immunogen
Recombinant protein of human DSC2
Conjugation
Unconjugated
Applications
WB
Dilution
WB 1:1000 - 1:2000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 100 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
DSC2 polyclonal antibody detects endogenous levels of DSC2 protein.
Applications Notes
Western blot analysis of extract of various cells, using DSC2 antibody.
Host or Source
Rabbit

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