DSC2 polyclonal antibody

• Background:

  This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  DG2; DSC3; CDHF2; ARVD11; DGII/III

• Swiss Prot:

  Q02487

• Reactivity:

  Human

• Immunogen:

  Recombinant protein of human DSC2

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB 1:1000 - 1:2000

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 100 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  DSC2 polyclonal antibody detects endogenous levels of DSC2 protein.

• Applications Notes:

  Western blot analysis of extract of various cells, using DSC2 antibody.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4