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IL6 polyclonal antibody

CAT: 0384-BS62100-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS62100-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Acute phase response is induced by interleukin-6 (IL-6) produced by T cells, macrophages, fibroblasts, endothelial and other cells . IL-6 induces proliferation or differentiation in many cell types including B cells, thymocytes and T cells. IL-6, in concert with TGF-β, is important for developing Th17 responses. IL-6 binds to IL-6Rα and through this association induces gp130 homodimerization . gp130 homodimerization triggers the Jak/Stat cascade and the SHP-2/Erk MAP kinase cascade . IL-6 also forms a complex with an IL-6Rα splice variant that is nonmembrane-associated . The IL-6/soluble IL-6Rα complex can then activate the gp130 signaling pathway in cells that express gp130 but not IL-6Rα . Research studies have shown that IL-6, through increasing expression of proangiogenic VEGF, may also contribute to metastatic breast cancer.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Interleukin-6; IL-6; B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2; IL6; IFNB2
Swiss Prot
P05231
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human IL6.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 28 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IL6 polyclonal antibody detects endogenous levels of IL6 protein.
Applications Notes
Western blot (WB) analysis of IL6 polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate (40ug) Lane2:U-87MG whole cell lysate (40ug) Lane3:HuT78 whole cell lysate (40ug) Lane4:A549 whole cell lysate (40ug) Lane5:MCF-7 whole cell lysate (40ug)
Host or Source
Rabbit

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