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TAC1 polyclonal antibody

CAT: 0384-BS60380-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS60380-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The tachykinin familyconsists of amidated neuropeptidesthatshare a carboxyterminalsequence (Phe-X-Gly-Leu-Met-NH2) . Preprotachykinin I, also designated protachykinin 1 precursor (PPT), is a common precursor of tachykinins. Preprotachykinin I alternatelysplicesto formvariousisoforms. These isoforms include: Substance P; Neurokinin A (NKA, Substance K, Neuromedin L) ; Neurokinin B; Neuropeptide K (NPK) ; Neuropeptide γ; and C-terminal flanking peptide. Substance P is expressesed primarilyin the small diameter primary sensoryfibers of the peripheral nervoussystem, and in the superficial dorsal horn of the spinalcord, the substantia nigra, and the medial amygdaloid nucleus of the central nervoussystem. Tachykinin peptides havemany plieotropicfunctionsincluding: neurotransmission, immune/ hematopoieticmodulation, angiogenesis andmitogenesis. Preprotachykinin I has been implicated in breastcancer and bonemarrowmetastasis. Substance P plays a role in depression.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Protachykinin-1; PPT; Substance P; Neurokinin A; NKA; Neuromedin L; Substance K; Neuropeptide K; NPK ; Neuropeptide gamma; C-terminal-flanking peptide; TAC1; NKA, NKNA, TAC2
Swiss Prot
P20366
Reactivity
Human, Rat
Immunogen
A synthetic peptide corresponding to residues in Human TAC1.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 50 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
TAC1 polyclonal antibody detects endogenous levels of TAC1 protein.
Applications Notes
Western blot (WB) analysis of TAC1 pAb at 1:500 dilution Lane1:PC3 whole cell lysate (40ug) Lane2:C6 whole cell lysate (40ug) Lane3:HCT116 whole cell lysate (40ug) Lane4:HEK293T whole cell lysate (40ug) Lane5:HUT78 whole cell lysate (40ug) Lane6:U-87MG whole cell lysate (40ug)
Host or Source
Rabbit

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