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GJA3 polyclonal antibody

CAT: 0384-BS61194-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS61194-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The connexin family of proteins form hexameric complexes called “connexons” that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane α-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains, the transmembrane and extracellular regions. Each of the approximately 20 connexin isoforms produces channels with distinct permeabilities and electrical and chemical sensitivities; therefore, one connexin usually cannot fully substitute for another. Consequently, a wide variety of malignant phenotypes associate with decreased connexin expression and gap junction communication, dependent on the particular connexin that is affected. For instance, deletion of the gene encoding connexin 46, normally expressed in the lens, produces severe cataracts.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Gap junction alpha-3 protein; Connexin-46; Cx46; GJA3
Swiss Prot
Q9Y6H8
Reactivity
Human
Immunogen
A synthetic peptide corresponding to residues in Human GJA3.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 53 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
GJA3 polyclonal antibody detects endogenous levels of GJA3 protein.
Applications Notes
Western blot (WB) analysis of GJA3 pAb at 1:500 dilution Lane1:HEK293T whole cell lysate (40ug) Lane2:THP-1 whole cell lysate (40ug) Lane3:PC3 whole cell lysate (40ug)
Host or Source
Rabbit

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