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PPP4R2 polyclonal antibody

CAT: 0384-BS62475-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS62475-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Serine/threonine-protein phosphatase 4 regulatory subunit 2, regulatory subunit of serine/threonine-protein phosphatase 4 (PP4) . May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Product Name Alternative
Serine/threonine-protein phosphatase 4 regulatory subunit 2; PPP4R2; SBBI57
Swiss Prot
Q9NY27
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human PPP4R2.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB:1:500~1:1000 IHC:1:50~1:200
Purity
The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 55 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PPP4R2 polyclonal antibody detects endogenous levels of PPP4R2 protein.
Applications Notes
Western blot (WB) analysis of PPP4R2 polyclonal antibody at 1:500 dilution LaneA:CT-26 whole cell lysate LaneB:PC12 whole cell lysate LaneC:Hela whole cell lysate
Host or Source
Rabbit

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