PHAX polyclonal antibody

CAT: 0384-BS62467-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS62467-01Size:50 µL
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Background
Phosphorylated adapter RNA export protein, a phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC) -bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA) . Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG) -capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Product Name Alternative
Phosphorylated adapter RNA export protein; RNA U small nuclear RNA export adapter protein; PHAX; RNUXA
Swiss Prot
Q9H814
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human PHAX.
Conjugation
Unconjugated
Applications
WB ICC
Dilution
WB:1:500~1:1000 ICC:1:50~1:200
Purity
The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 55 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PHAX polyclonal antibody detects endogenous levels of PHAX protein.
Applications Notes
Western blot (WB) analysis of PHAX polyclonal antibody at 1:500 dilution LaneA:L02 whole cell lysate LaneB:MCF-7 whole cell lysate LaneC:SP2/0 whole cell lysate LaneD:H9C2 whole cell lysate
Host or Source
Rabbit

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