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RASSF8 polyclonal antibody

CAT: 0384-BS62455-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS62455-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RASSF8 (Ras association (RalGDS/AF-6 or RA) domain (N-terminal) family member 8), also known as HoJ-1 (carcinoma-associated protein HoJ-1), is an evolutionarily conserved member of the N-terminal RASSF family which is also comprised of RASSF7, PAMCI (or RASSF9) and RASSF10. RASSF8 contains an N-terminal RA domain and is believed to participate in the Ras signaling pathway. A reciprocal chromosomal translocation involving the genes encoding RASSF8 and Fibulin-1 is associated with a complex form of synpolydactyly, a condition in which there are typically more than five digits on a hand or foot and patients exhibit webbing or fusion of fingers and toes. In addition, RASSF8 is capable of acting as a tumor suppressor in lung cancer, as is suggested by the ectopic expression of RASSF8 inhibiting anchorageindependent growth. This implies that the loss of functional RASSF8 may be implicated in the development of lung cancer.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Product Name Alternative
Ras association domain-containing protein 8; Carcinoma-associated protein HOJ-1; RASSF8; C12orf2
Swiss Prot
Q8NHQ8
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human RASSF8.
Conjugation
Unconjugated
Applications
WB
Dilution
WB:1:500~1:1000
Purity
The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 45,48 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
RASSF8 polyclonal antibody detects endogenous levels of RASSF8 protein.
Applications Notes
Western blot (WB) analysis of RASSF8 polyclonal antibody at 1:500 dilution LaneA:The testis tissue lysate of Rat LaneB:The testis tissue lysate of Mouse LaneC:Hela whole cell lysate LaneD:L02 whole cell lysate
Host or Source
Rabbit

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