GRTP1 polyclonal antibody

CAT: 0384-BS62384-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS62384-01Size:50 µL
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Background
Pituitary growth hormone (GH), also designated somatotropin, plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membranebound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GRTP1 (growth hormoneregulated TBC protein 1), also designated TBC1 domain family member 6, is a 336 amino acid protein with expression modulated by growth hormone. The TBC1 domain of GRTP1 is a region that is notably conserved among GTPaseactivating proteins, which characteristically play a role in the cell cycle and mitosis coordination. Interestingly, expression of GRTP1 is significantly upregulated in post-puberty testis and then maintained in the adult, suggesting that the germ cell may be the major site of GRTP1 function. There are two isoforms of GRTP1, which are a result of alternative splicing events.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Product Name Alternative
Growth hormone-regulated TBC protein 1; TBC1 domain family member 6; GRTP1; TBC1D6
Swiss Prot
Q5TC63
Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide, corresponding to Human GRTP1.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB:1:500~1:1000 IHC:1:50~1:200
Purity
The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 38 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
GRTP1 polyclonal antibody detects endogenous levels of GRTP1 protein.
Applications Notes
Western blot (WB) analysis of GRTP1 polyclonal antibody at 1:500 dilution LaneA:A549 whole cell lysate LaneB:Jurkat whole cell lysate LaneC:THP-1 whole cell lysate LaneD:PC12 whole cell lysate LaneE:Raw whole cell lysate
Host or Source
Rabbit

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