Products for Research Use Only
RegisterLogin

SIRT3 polyclonal antibody

CAT: 0384-BS62525-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0384-BS62525-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in an NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologues, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT3 is a NAD-dependent deacetylase that contains one deacetylase sirtuin-type domain. The SIRT3 protein is widely expressed and localizes to the mitochondira where it is processed by mitochondrial processing peptidase (MPP) to yield a final product. This processing is most-likely necessary for its enzymatic activity.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
NAD-dependent protein deacetylase sirtuin-3, mitochondrial; hSIRT3; Regulatory protein SIR2 homolog 3; SIR2-like protein 3; SIRT3; SIR2L3
Swiss Prot
Q9NTG7
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to Human SIRT3.
Conjugation
Unconjugated
Applications
WB
Dilution
WB:1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 44 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SIRT3 polyclonal antibody detects endogenous levels of SIRT3 protein.
Applications Notes
Western blot (WB) analysis of SIRT3 polyclonal antibody at 1:500 dilution LaneA:HCT116 whole cell lysate
Host or Source
Rabbit

Related Products

CatalogName
MB11599SIRT3 monoclonal antibody
BS45210-01SIRT3 Recombinant Rabbit mAb
BS49013-01SIRT3 Recombinant Rabbit mAb
BS70805SIRT6 polyclonal antibody
BS6494-01SIRT1 polyclonal antibody
BS67339SIRT1 polyclonal antibody
BS70820-01SIRT4 polyclonal antibody
BZ16396-01SIRT1 polyclonal antibody
BS91248SIRT6 polyclonal antibody
BS91246SIRT2 polyclonal antibody

Alternative Products

CatalogName
MBS8572604-01SIRT3 Polyclonal Antibody
APR09956GPolyclonal SIRT3 Antibody

Popular Products