CDYL2 polyclonal antibody

• Background:

  CDY is a gene family expressed exclusively in the testis that localizes to a region of the Y chromosome frequently deleted in infertile males. CDY proteins contain two functional domains, an N-terminal chromodomain, possibly functioning in heterochromatin interactions, and a C-terminal domain, which resembles enoyl-CoA-isomerase, a protein involved in fatty acid oxidation. Furthermore, CDY proteins act as histone acetyltransferases with strong preference for Histone H4, a process required for the histone to proamine transition in spermatogenesis, consistent with the association with male infertility. Chromodomain Y-like protein 2 (CDYL2) is a related nuclear protein that is ubiquitously expressed with moderate levels in most tissues. The gene encoding CDYL2 is located on chromosome 16.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  Chromodomain Y-like protein 2; CDY-like 2; CDYL2

• Swiss Prot:

  Q8N8U2

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide, corresponding to Human CDYL2.

• Conjugation:

  Unconjugated

• Applications:

  WB IHC ICC

• Dilution:

  WB:1:500~1:1000 IHC:1:50~1:200 ICC:1:50~1:200

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 57 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  CDYL2 polyclonal antibody detects endogenous levels of CDYL2 protein.

• Applications Notes:

  Western blot (WB) analysis of CDYL2 polyclonal antibody at 1:500 dilution LaneA:CT26 whole cell lysate LaneB:PC12 whole cell lysate LaneC:Hela whole cell lysate LaneD:PC3 whole cell lysate

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4