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SLC2A1 polyclonal antibody

CAT: 0384-BS1149-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS1149-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Glucose transporter 1 (Glut1, SLC2A1) is a widely expressed transport protein that displays a broad range of substrate specificity in transporting a number of different aldose sugars as well as an oxidized form of vitamin C into cells . Glut1 is responsible for the basal-level uptake of glucose from the blood through facilitated diffusion . Research studies show that Glut1 and the transcription factor HIF-1α mediate the regulation of glycolysis by O-GlcNAcylation in cancer cells . Additional studies demonstrate that Glut1 is required for CD4 T cell activation and is critical for the expansion and survival of T effector (Teff) cells . Mutations in the corresponding SLC2A1 gene cause GLUT1 deficiency syndromes (GLUT1DS1, GLUT1DS2), a pair of neurologic disorders characterized by delayed development, seizures, spasticity, paroxysmal exercise-induced dyskinesia, and acquired microcephaly . Two other neurologic disorders - dystonia-9 (DYT9) and susceptibility to idiopathic generalized epilepsy 12 (EIG12) - are also caused by mutations in the SLC2A1 gene .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Product Name Alternative
Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; SLC2A1
Swiss Prot
P11166
Reactivity
Human, Rat
Immunogen
Synthetic peptide, corresponding to Human SLC2A1.
Conjugation
Unconjugated
Related Pathways
Warburg Effect, Insulin &Glucose Signaling, Glutamine Metabolism
Applications
WB
Dilution
WB: 1:1000~1:2000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 50 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
SLC2A1 polyclonal antibody detects endogenous levels of SLC2A1 protein.
Applications Notes
Western blot (WB) analysis of SLC2A1 polyclonal antibody at 1:500 dilution Lane1:PC12 whole cell lysate (40ug) Lane2:SGC7901 whole cell lysate (40ug) Lane3:EC9706 whole cell lysate (40ug)
Host or Source
Rabbit

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