DAB2 Polyclonal Antibody

• Background:

  This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene

• Structure Composition:

  0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Product Name Alternative:

  DAB 2; DAB2; DAB2_HUMAN; Differentially expressed protein 2; Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein) ; disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein) ; Disabled homolog 2; Disabled homolog 2 mitogen responsive phosphoprotein (Drosophila) ; Disabled homolog 2 mitogen responsive phosphoprotein; disabled homolog 2 mitogen-responsive phosphoprotein (Drosophila) ; DOC 2; DOC2; FLJ26626; Mitogen responsive phosphoprotein.

• Swiss Prot:

  P98082

• Reactivity:

  Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig

• Immunogen:

  KLH conjugated synthetic peptide derived from human DAB2:31-130/770

• Conjugation:

  Unconjugated

• Applications:

  FCM

• Dilution:

  Flow-Cyt=1ug/Test

• Purity:

  Affinity purified by Protein A

• Modification:

  Unmodification

• Molecular Weight:

  82kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  DAB2 Polyclonal Antibody detects endogenous levels of DAB2 protein.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4