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CRB2 Polyclonal Antibody

CAT: 0384-BS65770-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS65770-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CRB2 is a 1,285 amino acid protein that contains three laminin G-like domains and 15 EGF-like domains and exists as multiple alternatively spliced isoforms that are either secreted or membrane bound. Expressed in kidney and retina, as well as in fetal eye and brain, CRB2 is thought to play a role in the morphogenesis of polarized cells and may be involved in DNA repair. Defects in the gene encoding CRB2 are associated with the pathogenesis of autosomal recessive retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA), the former of which refers to a group of diseases that lead to the degeneration of retinal photoreceptor cells, ultimately resulting in a loss of vision. The gene encoding CRB2 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome.
CAS Number
9007-83-4
Structure Composition
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Product Name Alternative
Crb2; CRUM2_HUMAN; Crumbs homolog 2 (Drosophila) ; Crumbs homolog 2; Crumbs-like protein 2; RP11-230L22.2.
Swiss Prot
Q5IJ48
Reactivity
Human, Mouse, Rat
Immunogen
KLH conjugated synthetic peptide derived from human CRB2:701-800/1285
Conjugation
Unconjugated
Applications
WB
Dilution
WB=1:500-2000
Purity
Affinity purified by Protein A
Modification
Unmodification
Molecular Weight
100,131 kD
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CRB2 Polyclonal Antibody detects endogenous levels of CRB2 protein.
Applications Notes
Primary: Anti- CRB2 at 1/1000 dilution
Host or Source
Rabbit

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