CSAD Polyclonal Antibody

• Background :

  CSAD is a 493 amino acid protein that exists as a homodimer and belongs to the group II decarboxylase family. CSAD catalyzes the conversion of 3-sulfino-L-alanine to hypotaurine and carbon dioxide, binds pyridoxal phosphate as a cofactor and undergoes alternative splicing to produce three isoforms. The gene encoding CSAD maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.

• CAS Number :

  9007-83-4

• Structure Composition :

  0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Product Name Alternative :

  CSAD; CSAD_HUMAN; CSD; Cysteine sulfinic acid decarboxylase; Cysteine-sulfinate decarboxylase; Sulfinoalanine decarboxylase.

• Swiss Prot :

  Q9Y600

• Reactivity :

  Human, Mouse, Rat, Dog, Horse

• Immunogen :

  KLH conjugated synthetic peptide derived from human CSAD:401-493/493

• Conjugation :

  Unconjugated

• Applications :

  IHC-P

• Dilution :

  IHC-P=1:100-500

• Purity :

  Affinity purified by Protein A

• Modification :

  Unmodification

• Molecular Weight :

  55kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  CSAD Polyclonal Antibody detects endogenous levels of CSAD protein.

• Applications Notes :

  Paraformaldehyde-fixed, paraffin embedded (rat brain) ; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CSAD) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C

• Host or Source :

  Rabbit