Beta-casein polyclonal antibody

• Background:

  Milk proteins are crucial for the development of all newborn mammals and caseins constitute the major proteins in mammalian milk. b- and k-caseins are the only caseins present in human milk. The b-casein/k-casein ratio is higher in colostrum than in transitional and mature milk and is related to a better digestibility of colostrum casein micelles by the neonate during the first days of life. Human b-casein-encoding gene (Bca) contains a highly phosphorylated site, which is responsible for the calcium-binding capacity of b-casein. A common set of transcription factors are required for the expression of b-casein. Multiple binding sites for Stat5, C/EBPb (CCAAT/enchancer-binding protein) and several half-sites for glucocorticoid receptor (GR) are identified in the distal human enhancer of the b-casein gene. b-casein gene transcription is regulated primarily by a composite response element (CoRE), which integrates signaling from the lactogenic hormones PRL, insulin and hydrocortisone in mammary epithelial cells. NFkB functions as a negative regulator of b-casein gene expression during pregnancy by interfering with Stat5 tyrosine phosphorylation

• Structure Composition:

  0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Product Name Alternative:

  Beta-casein; Casoparan; Antioxidant peptide; Casohypotensin; CASB; CASB_BOVIN; Casein beta; CSN 2; Csn2; CASB_BOVIN.

• Swiss Prot:

  P10598

• Reactivity:

  Mouse, Rat

• Immunogen:

  KLH conjugated synthetic peptide derived from mouse Beta-casein:171-231/231

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

• Purity:

  Affinity purified by Protein A

• Modification:

  Unmodification

• Molecular Weight:

  ~25-29kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  Beta-casein polyclonal Antibody detects endogenous levels of Beta-casein protein.

• Applications Notes:

  Anti-Beta-casein at 1/1000 dilution

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4