GIMAP1 Polyclonal Antibody

• Background:

  The GTPase of the immunity-associated protein (GIMAP) family of proteins include seven members that are expressed by genes residing on human chromosome 7. GIMAP proteins have been implicated in the regulation of lymphomyeloid cell survival. GIMAP1 (GTPase, IMAP family member 1), also known as IMAP1 (immunity-associated protein 1), HIMAP1 or IMAP38, is a 306 amino acid single-pass type IV membrane protein of the endoplasmic reticulum (ER) belonging to the GIMAP family. Encoded by a gene located on human chromosome 7, GIMAP1 is expressed primarily in spleen with lower levels found in lymph node. Chromosome 7 houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.

• Structure Composition:

  0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Product Name Alternative:

  GIMA1_HUMAN; GIMAP1; GTPase IMAP family member 1; hIMAP1; Immunity-associated protein 1.

• Swiss Prot:

  Q8WWP7

• Reactivity:

  Human, Mouse, Rat, Horse, Rabbit

• Immunogen:

  KLH conjugated synthetic peptide derived from human GIMAP1:31-130/306

• Conjugation:

  Unconjugated

• Applications:

  IHC-P

• Dilution:

  IHC-P=1:100-500

• Purity:

  Affinity purified by Protein A

• Modification:

  Unmodification

• Molecular Weight:

  34kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  GIMAP1 Polyclonal Antibody detects endogenous levels of GIMAP1 protein.

• Applications Notes:

  Paraformaldehyde-fixed, paraffin embedded (rat lymphoid) ; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GIMAP1) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4