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GPD2 polyclonal antibody

CAT: 0384-BS8295-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS8295-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GPD2 (glycerol-3-phosphate dehydrogenase 2, mitochondrial), also known as GDH2 or GPDM, is a 727 amino acid protein belonging to the FAD-dependent glycerol-3-phosphate dehydrogenase family. GPD2 is involved in the conversion of glycerol-3-phosphate (G-3-P) to dihydroxyacetone phosphate (DHAP) while reducing enzyme-bound FAD. Localizing to the outer surface of the inner mitochondrial membrane, GPD2 acts in conjunction with GPD1 (a cytosolic NAD-linked GPD) to form a glycerol phosphate shuttle that ultimately results in the reoxidation of NADH formed during glycolysis. While widely expressed in adult and fetal tissue, GPD2 is found at highest levels in human pancreatic islets where it is essential for pancreatic B-cell glucose-sensory function. Decreased levels of GPD2 leads to impaired glucose-stimulated insulin release in noninsulin-dependent diabetes mellitus. Existing as two alternatively spliced isoforms, GPD2 contains two EF-hand domains and maps to human chromosome 2q24.1.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Glycerol-3-phosphate dehydrogenase, mitochondrial; GPD-M; GPDH-M; mtGPD; GPD2
Swiss Prot
P43304
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 25-325 of human GPD2 (NP_000399.3) .
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:2000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 81 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
GPD2 polyclonal antibody detects endogenous levels of GPD2 protein.
Applications Notes
Western blot analysis of extracts of various cell lines, using GPD2 Rabbit pAb at 1:1000 dilution.
Host or Source
Rabbit

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