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STAT2 polyclonal antibody

CAT: 0384-BS91285-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS91285-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-a and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
STAT2, Homo sapiens interferon alpha induced transcriptional activator, interferon alpha induced transcriptional activator, ISGF 3, ISGF3, MGC59816, P113, signal transducer and activator of transcription 2 113kD, Signal transducer and activator of transcription 2, STAT113, Stat2, STAT2
Swiss Prot
P52630
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to Human STAT2.
Conjugation
Unconjugated
Related Pathways
Jak Stat : IL-6 Receptor Signaling
Applications
WB IP
Dilution
WB:1:1000~1:2000 IP:1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 113 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
STAT2 polyclonal antibody detects endogenous levels of STAT2 protein.
Applications Notes
Western blot (WB) analysis of Stat5a/b pAb at 1:1000 dilution Lane1:HepG2 whole cell lysate (20ug) Lane2:U-87MG whole cell lysate (20ug)
Host or Source
Rabbit

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