RegisterLogin

JAK2 polyclonal antibody

CAT: 0384-BS90749-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS90749-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
JAK2 (Janus kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
JAK-2; JAK2; Janus Activating Kinase 2; Janus kinase 2 (a protein tyrosine kinase) ; Janus kinase 2; ; JTK10; kinase Jak2; OTTHUMP00000043260; THCYT3; Tyrosine protein kinase JAK2; Tyrosine-protein kinase JAK2
Swiss Prot
O60674
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB:1:2000~1:5000 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 130 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
JAK2 polyclonal antibody detects endogenous levels of JAK2 protein.
Applications Notes
Western blot (WB) analysis of JAK2 pAb at 1:2000 dilution Lane1:Hela whole cell lysate (40ug) Lane2:U-87MG whole cell lysate (40ug) Lane3:AML-12 whole cell lysate (40ug) Lane4:H9C2 whole cell lysate (40ug)
Host or Source
Rabbit

Related Products

CatalogName
BS2432-01JAK2 (R564) polyclonal antibody
BS1194JAK2 (L1001) polyclonal antibody
BS4610-01JAK2 (phospho-Y570) polyclonal antibody
BS79429-01Phospho-JAK2-Y1008 polyclonal antibody
BS79457-01Phospho-JAK2-Y1007 polyclonal antibody
BZ16410-01Phospho-JAK2 (Tyr1007) polyclonal antibody
BS4109-01Phospho-JAK2-Y1007/1008 polyclonal antibody
BS94058JAK2 (Phospho-Y1007/Y1008) polyclonal antibody
MB11128JAK2 monoclonal antibody
BZ16115-01Phospho-JAK2/3 (Tyr966/939) polyclonal antibody

Alternative Products

CatalogName
MBS8573527-01JAK2 Polyclonal Antibody

Popular Products