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HNF4α polyclonal antibody

CAT: 0384-GCP110-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-GCP110-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver. HNF4α, in association with PGC-1α, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers. Conditional knockout of the HNF4α gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels. Mutations in HNF4α have been linked to maturity-onset diabetes of the young (MODY) .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Hepatocyte nuclear factor 4-alpha; HNF-4-alpha; Nuclear receptor subfamily 2 group A member 1; Transcription factor 14; TCF-14; Transcription factor HNF-4
Swiss Prot
P41235
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to Human HNF4α.
Conjugation
Unconjugated
Related Pathways
Nuclear Receptor Signaling
Applications
WB IHC
Dilution
WB: 1:1000~1:2000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 58 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
HNF4α polyclonal antibody detects endogenous levels of HNF4α protein.
Applications Notes
Western blot (WB) analysis of HNF4α polyclonal antibody at 1:2000 dilution Lane1:HepG2 whole cell lysate (40ug) Lane2:A549 whole cell lysate (40ug)
Host or Source
Rabbit

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