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COUP-TFI polyclonal antibody

CAT: 0384-GCP117-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-GCP117-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Chicken ovalbumin upstream promoter transcription factor (COUP-TF) belongs to the NR2 subfamily of the nuclear hormone receptor family. COUP-TFI and COUP-TFII are two of the well-characterized members in the NR2 subfamily. These two members are highly conserved in their two zinc-finger DNA binding domains (DBD) and the ligand binding domain (LBD), and function as repressors or activators of downstream target genes to regulate different biological processes. COUP-TFI and II bind to 5'-AGGTCA-3' motif palindromes, either directly or indirectly, through heterodimer formation with other proteins (e.g. RXRs) to regulate downstream target gene expression. COUP-TFI is involved in neuronal development, tissue patterning, and differentiation. COUP-TFII has been shown to be involved in angiogenesis, glucose homeostasis, and mesenchymal cell commitment.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
COUP transcription factor 2; COUP-TF2; Apolipoprotein A-I regulatory protein 1; ARP-1; COUP transcription factor II; COUP-TF II; Nuclear receptor subfamily 2 group F member 2; NR2F2; ARP1, TFCOUP2
Swiss Prot
P24468
Reactivity
Pig
Immunogen
Synthetic peptide, corresponding to Human COUP-TFI.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:5000~1:10000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 52 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
COUP-TFI polyclonal antibody detects endogenous levels of COUP-TFI protein.
Applications Notes
Western blot (WB) analysis of COUP-TFI polyclonal antibody at 1:10000 dilution Lane1:The Heart tissue lysate of Pig (40ug) Lane2:The Brain tissue lysate of Pig (40ug)
Host or Source
Rabbit

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