EphB1/2 polyclonal antibody

CAT: 0384-BS1743-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS1743-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. Beside its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.
CAS Number
9007-83-4
Structure Composition
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Product Name Alternative
Eph receptor B1+Eph receptor B2; EPH B1; EPH B2; Eph tyrosine kinase 2; Eph tyrosine kinase 3; EPHB1; EPHB2; Ephrin receptor EphB1; Ephrin receptor EphB2; Ephrin type B receptor 1; Ephrin type B receptor 2; EPHT 2; EPHT 3; ERK; Hek 5; Hek 6; Tyrosine protein kinase receptor EPH2; Tyrosine protein kinase receptor EPH3; EPHB1_HUMAN
Swiss Prot
P54762
Reactivity
Human, Mouse, Rat
Immunogen
KLH conjugated synthetic peptide derived from human EphB1+EphB2: 901-984/984
Conjugation
Unconjugated
Applications
WB IF IHC ELISA
Dilution
WB: 1:500~1:2000 IHC: 1:100~1:500 IF: 1:100~1:500 ELISA: 1:5000~1:10000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 125 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
EphB1/2 polyclonal antibody detects endogenous levels of EphB1/2 protein.
Applications Notes
Sample: Large intestine (Mouse) Lysate at 40 ug Testis (Mouse) Lysate at 40 ug Primary: Anti-EphB1/2 at 1/300 dilution
Host or Source
Rabbit

Related Products

CatalogName
BS61383-01EPHB1/EPHB2/EPHB3 polyclonal antibody
BS79074EPHB1 polyclonal antibody
BS3742-01EphB1/2/3/4 (Y594) polyclonal antibody
MB66630-01EPHB1 monoclonal antibody
PPL50062-2aPDsRed1-N1-Ephb1
BS78435EPHB4 polyclonal antibody
BS71778-01EPHB2 polyclonal antibody
BS75924EPHB6 polyclonal antibody
BS6593EPHX1 polyclonal antibody
BS60027-01EphB3 polyclonal antibody

Alternative Products

CatalogName
MBS8592186-01EphB1/2 Polyclonal Antibody
ABP54134-01EphB1/2/3 Polyclonal Antibody
MBS9449779-01EphB1/2 Polyclonal Conjugated Antibody
APRab10524-01EphB1/2 Rabbit Polyclonal Antibody
MBS2575557-01EPHB1 Polyclonal Antibody
MBS9613672-01EPHB1/2 Antibody
abx141026-01EPHB1 / 2 Antibody

Popular Products